A man has died after his car went off the road in Clayton before hitting a power pole and a tree, before bursting into flames.

The crash occurred in the median strip on Wellington Road, between Cambro and Renver Roads just after midnight, Tuesday.

Sergeant Adrian Stafferton said the car was travelling west in the right lane before it mounted the curb and flew through the air and crashed into a pole and large tree.

Police were on the scene almost straight away and passers-by had been trying to open the door to get the man out.

However, Sergeant Stafferton said the man had died instantly.

There is no suspicion that the man was speeding.

Anyone who witnessed the collision is urged to contact Crime Stoppers on 1800 333 000 or submit a confidential report at crimestoppersvic.com.au.